In the early 1950s he created his celebrated cycles of works: “Scontro di situazioni” (Collision of Situations), “Ciclo della Protesta” (Protest Cycle), “Cicli della Natura” (Cycles of Nature). In 1954, at the second São Paolo Art Biennial he won a prize that would allow him to spend three months in Brazil, where he encountered an extreme, hard reality that would leave its mark on him. In 1961 he designed the sets and costumes for Luigi Nono’s “Intolleranza ‘60” (Intolerance ’60); in 1984 he would work with the composer again on “Prometeo”. From 1961 onwards he worked on his “Plurimi” creating an initial Venetian series followed by works made from 1963 to 1964 in Berlin including the seven pieces forming the “Absurdes Berliner Tagebuch ‘64” (Absurd Berlin Diary ’64) presented at the 1964 Kassel Documenta where he also showed in 1955, 1959 and 1982. From 1965 to 1967 he worked on “Spazio/Plurimo/Luce” (Space/Plurimo/Light) for the MontrealEXPO. He carried out intense teaching activities in various American universities followed by the Sommerakademie in Salzburg and the Academy of Venice. In the 1970s he created the “Plurimi Binari” in the “Lacerazione” (Laceration) and “Carnevali” (So-called carnivals) cycles followed by the vast cycles of “teleri” (big canvases) and his “Disks”, “Tondi”, “Oltre” (Beyond) and “…in continuum…” works. He won numerous prestigious prizes and awards. His last important solo exhibitions included the major retrospective held at Castello di Rivoli in 1998 and, after his death in 2006, the sister shows at Rome’s Galleria Nazionale d’Arte Moderna and the Berlinische Galerie (Berlin).
His artistic career was characterised by a constant desire to explore and innovate. Vedova joined the anti-Novecento movement known as “Corrente”. An anti-Fascist, he worked for the Resistance from 1944 to 1945 and in 1946, he was one of the co-signers of the “Oltre Guernica” manifesto in Milan. In the same year in Venice he was one of the founders of the “Nuova Secessione Italiana” followed by the “Fronte Nuovo delle Arti”. In 1948 he made his debut in the Venice Biennale, the first of many appearances in this event: in 1952 an entire room was devoted to his work, in 1960 he was awarded the Grand Prize for Painting and in 1997 the prestigious Golden Lion award for Lifetime Achievement.